Fabio A. Varón-Vega, Critical Care and Lung transplantation Service, Fundación Neumológica Colombiana, Fundación Cardio Infantil, Bogotá; Critical Care Service, Fundación Neumológica Colombiana, Fundación Cardio Infantil, Bogotá; Colombia
Adriana Rincón, Critical Care Service, Fundación Neumológica Colombiana, Fundación Cardio Infantil, Bogotá, Colombia
Eduardo Tuta-Quintero, Department of Internal Medicine, School of Medicine, Universidad de La Sabana, Chía, Colombia
Catalina González-Avilés, Department of Internal Medicine, School of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia
Leidy P. Prada, Critical Care Service, Fundación Neumológica Colombiana, Fundación Cardio Infantil, Bogotá, Colombia
Luis J. Téllez, Thoracic Surgery, La Cardio, Bogotá, Colombia
Objective: Survival in lung transplantation (LT) may be influenced by recipient-related variables, donor factors, donor-recipient interaction, surgical approach, and medical center expertise. The objective of this study was to describe the sociodemographic, clinical characteristics, and survival of patients who have undergone LT. Method: We conducted an observational analysis between 2014 and 2022. Survival was calculated using the Kaplan-Meier method at the 1st, 3rd, and 5th years of follow-up posttransplantation. Results: We analyzed data from 50 subjects, of whom 56% (28/50) were men, with a median age of 54 years (interquartile range: 39-59). The unadjusted survival rates post lung transplantation were 81.4% at 12-months, 65.8% at 3-years, and 53.6% at 5-years. Excluding mortality attributed to COVID-19, survival rates were 78.2% at 12-months, 68.8% at 3-years, and 63.5% at 5-years. The survival of pulmonary fibrosis with a non-usual interstitial pneumonia (N-UIP) pattern was 85% at 1 year and 54% at 5 years, while pulmonary fibrosis with a usual interstitial pneumonia (UIP) pattern demonstrated a solid survival rate of 80% at 1 year and 60% at 5 years. Conclusions: Patients with pulmonary fibrosis with a N-UIP pattern demonstrated superior survival after 1 year of follow-up, while those with pulmonary fibrosis with a UIP pattern described the highest survival at the 5th year. COVID-19 decreased long-term survival in transplant patients.
Keywords: Lung transplantation. High altitude. Survival.