The role of collagen type I/III ratio in the etiology of sacrococcygeal pilonidal




Arif Atay, Department of General Surgery, Izmir Katip Celebi University Atatürk Training and Research Hospital, Izmir, Turkey
Ilknur Kucukosmanoglu, Department of Pathology, Saglik Bilimleri University, Faculty of Medicine, Konya Education and Research Hospital, Konya, Turkey
Hande Köksal, Department of General Surgery, Saglik Bilimleri University, Faculty of Medicine, Konya Education and Research Hospital, Konya. Turkey
Kemal Arslan, Department of General Surgery, Saglik Bilimleri University, Faculty of Medicine, Konya Education and Research Hospital, Konya. Turkey
Osman Dogru, Department of General Surgery, Saglik Bilimleri University, Faculty of Medicine, Konya Education and Research Hospital, Konya. Turkey


Objective: The purpose of this study is to investigate whether there was a difference between the midline skin and the healthy skin in the lateral by means of total amount of collagen and Type I/III ratio which was the indicator of the collagen structure. Material and methods: Fifty patients with pilonidal sinus disease were enrolled. Samples were prepared from the midline skin of the sinus where the holes were located and lateral skin of the resected material. Results: It was determined that the lateral line had significantly more collagen intensity and a higher collagen Type I/III ratio (p < 0.001). Conclusions: One of the reasons why hair mostly pricks into the midline in the intergluteal sulcus in pilonidal sinus disease is the fact that the amount of total collagen and collagen Type I/III ratio of the midline are lower than those of the lateral tissue. Complications are more common in cases with low Type I/III ratio and low total collagen rates.10.24875/CIRU.21000498



Palabras clave: Pilonidal sinus. Etiopathogenesis. Total collagen. Collagen type 1/3 ratio.