Bahattin Aydogdu, Department of Pediatric Surgery, Faculty of Medicine, Dicle University. Dıyarbakır, Turkey
Erol Basuguy, Department of Pediatric Surgery, Faculty of Medicine, Dicle University. Dıyarbakır, Turkey
Serkan Arslan, Erol Basuguy Department of Pediatric Surgery, Faculty of Medicine, Dicle University. Dıyarbakır, Turkey
Mustafa Azizoğlu, Department of Pediatric Surgery, Faculty of Medicine, Dicle University. Dıyarbakır, Turkey
İbrahim Ibiloglu, Department of Pathology, Faculty of Medicine, Dicle University. Dıyarbakır, Turkey
İbrahim Kaplan, Department of Biochemistry, Faculty of Medicine, Dicle University. Dıyarbakır, Turkey
Gulay Aydogdu, Department of Pathology, Faculty of Medicine, Dicle University. Dıyarbakır, Turkey
Mehmet Hanifi-Okur, Department of Pediatric Surgery, Faculty of Medicine, Dicle University. Dıyarbakır, Turkey


Objective: None of studies have been conducted in terms of demonstrating the same effect with the low dose in cordycepin. In our study, we analyzed the histopathological and biochemical changes of low-dose Cordycepin(c) on a rat model in the kidney. Materials and methods: Twenty-four male Wistar Albino rats were randomly allocated to three groups (n = 8): the sham-control group (Group 1), the renal I/R-untreated (Group 2) group, and the I/R-C-treated (Group 3) group. Cordyceps was administered intraperitoneally at 5 mg/kg twice. Renal histological changes were compared and the relevant parameters of oxidative stress and inflammation were detected. Results: In blood and tissue biochemistry, it was observed that IL-1 Beta, IL 6, TNF alpha, MDA, TOS, and OSI increased in Group 2 and decreased in Group 3. It was determined that TAS values were increased in Group 3, and decreased in Group 2. In the histopathological evaluation, while Group 1 was evaluated as normal, significant kidney damage was detected in Group 2. It was determined that there was a significant decrease in kidney damage in Group 3. Conclusion: These results suggest that low dose Cordycepin was as effective as normal dose on renal ischemic reperfusion and reduction of damage.



Keywords: Cordyceps. Ischemia-reperfusion injury. Kidney.