Mahmut Padak, Department of Perfusion Techniques, Harran University Vocational School of Health Services, Şanlıurfa, Türkiye
Reşat Dikme, Department of Dialysis Program, Harran University Vocational School of Health Services, Şanlıurfa, Türkiye
Ebru Temiz, Harran University Vocational School of Health Services, Şanlıurfa, Türkiye
Ömer Göç, Department of Biomedical Device Technology, Harran University Vocational School of Health Services, Şanlıurfa, Türkiye
Ezhar Ersöz, Harran University, Research and Application Hospital, Şanlıurfa, Türkiye
Yasemin Hacanlı, Harran University, Research and Application Hospital, Şanlıurfa, Türkiye
Objective: This study was conducted to investigate the levels of nuclear factor (erythroid derivative 2)-like 2 (NRF-2), kidney injury molecule 1 (KIM-1), and heme oxygenase-1 (HO-1) in pericardial fluid (PF) and systemic circulation of patients undergoing cardiac surgery. Methods: This study included 40 patients undergoing cardiac surgery and 40 healthy individuals. PF and venous blood samples were obtained from the patients and renal function tests, HO-1, KIM-1, NRF-2, antioxidant, and oxidative stress parameters were studied. Results: A statistically significant difference was found in the NRF-2, KIM-1, HO-1, total antioxidant status, total oxidant status, and oxidative stress index measurements in the plasma of the patient and control groups and in the PF of the patients (p < 0.01). Compared to the control group, NRF-2, KIM-1, and HO-1 were found to be lower in the patient’s plasma and PF. In the patient group, NRF-2, KIM-1, HO-1, and KIM-1 were higher in PF compared to plasma. Conclusions: In the future, intrapericardial drug administration may improve cardiac function and prevent the adverse cardiorenal syndrome on the kidney.
Keywords: Kidney damage. Nuclear factor (erythroid derivative 2)-like 2. Kidney injury molecule 1. Heme oxygenase-1. Cardiopulmonary bypass. Cardiac surgery.