Bişar Amaç, Department of Perfusion, Faculty of Health Sciences, Harran University, Sanliurfa, Turkey
Murat Ersoy, Department of Cardiovascular Surgery, University of Health Sciences, Sanliurfa Mehmet Akif Inan, Training and Research Hospital, Sanliurfa, Turkey
Murat Z. Bağiş, Department of Cardiovascular Surgery, Faculty of Medicine, Harran University, Sanliurfa, Turkey
Mahmut Padak, Department of Perfusion, Faculty of Health Sciences, Harran University, Sanliurfa, Turkey
Objectives: The difference between mean arterial pressure (MAP) before cardiopulmonary bypass (CPB) and mean perfusion pressure (MPP) during CPB is thought to be a strong predictor of acute kidney injury (AKI). In this study, we aimed to evaluate whether the difference between MAP and MPP is a good index to predict the development of AKI and what the ideal MPP should be during CPB. Methods: A total of 296 consecutive patients were included in this retrospective study. MAP-MPP differences of patients who developed AKI and those who did not develop AKI according to standard guidelines and their relation with adverse outcomes were evaluated. Results: MAP values of patients who did not develop AKI and patients who developed AKI were higher in the group with AKI, 67.60 mmHg versus 64.84 mmHg (p = 0.001). The MAP-MPP difference was 5.07 in the group without AKI and 9.44 in the group with AKI (p = 0.000). Conclusion: We found that the difference between MAP and MPP is a good index for predicting the development of CPB-related AKI and poor outcomes. We also suggest that patients’ preoperative arterial blood pressure should be taken into account for an ideal MPP.
Keywords: Cardiopulmonary bypass. Mean arterial pressure. Mean perfusion pressure. Acute kidney injury. Mean arterial pressure-mean perfusion pressure difference.