Junhui Ji, Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Xiafang Gu, Department of Anesthesiology, Suzhou City Xiangcheng District Second People’s Hospital, Suzhou, Jiangsu Province, China
Jingjing Xu, Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Ke Peng, Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Chengjiao Xiao, Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
Objective: The objective of the study was to analyze the application value of opioid-free anesthesia (OFA) in renal cyst decompression by laparoscopy. Method: A total of 124 patients undergoing renal cyst decompression by laparoscopy in our hospital were selected and divided into opioid anesthesia (OA) and OFA groups (n = 62). Fentanyl and remifentanil were used for anesthesia induction in the OA group, while lidocaine and dexmedetomidine were employed for anesthesia induction in the OFA group. The homeostasis indicators (cortisol [Cor], adrenocorticotropic hormone [ACTH], C-reactive protein [CRP], and interleukin-6 [IL-6]) were also compared 10 min before anesthesia (Ta), at the end of operation (Tb), and 24 h after operation (Tc). Results: At T1-T3, heart rate, mean arterial pressure, mean airway pressure, and partial pressure of end-tidal carbon dioxide were all lower in OFA group than those in OA group (p < 0.05). At Tb-Tc, the levels of Cor, ACTH, CRP, and IL-6 were all higher in both groups than those at Ta (p < 0.05), while they were lower in OFA group than those in OA group (p < 0.05). Conclusion: OFA is more beneficial to the respiratory and circulatory system and homeostasis of patients, and has higher anesthetic safety.
Keywords: Renal cyst decompression. Laparoscopy. Opioid-free. Anesthesia. Respiratory circulatory system.