Kemal Eyvaz, Department of General Surgery, University of Health Sciences, Antalya Education and Research Hospital, Antalya, Turkey
Onur Dinçer, Department of General Surgery, University of Health Sciences, Antalya Education and Research Hospital, Antalya, Turkey
Erhan Aydemir, Department of General Surgery, University of Health Sciences, Antalya Education and Research Hospital, Antalya, Turkey
Murat Kazim-Kazan, Department of General Surgery, University of Health Sciences, Antalya Education and Research Hospital, Antalya, Turkey
Nedim Akgül, Department of General Surgery, University of Health Sciences, Antalya Education and Research Hospital, Antalya, Turkey
Arif Aslaner, Department of General Surgery, University of Health Sciences, Antalya Education and Research Hospital, Antalya, Turkey
Tuğrul Çakir, Department of General Surgery, University of Health Sciences, Antalya Education and Research Hospital, Antalya, Turkey
Objective: We would like to investigate the prognostic utility of the previously described factors and offer a new parameter called neutrophil-to-C-reactive protein ratio (NCR) as a predictor of post-operative complications of pancreas cancer. Methods: 92 patients underwent pancreaticoduodenectomy for the pancreatic head tumor were enrolled in this study. Receiver operating curve analysis was performed to detect the cutoff values, and logistic regression analyses were performed to identify the independent risk factors of complications. Results: In univariate analysis, complications were observed in lymphocyte-to-C-reactive protein ratio levels below 0.06 (Odds Ratio [OR]: 3.92, 95% confidence interval [CI] = 1.08-14.21, p = 0.037). In multivariate analysis, albumin < 3.6 (OR: 3.25, 95% CI: 1.16-9.06, p = 0.024) and NCR < 0.28 (OR: 2.81, 95 % CI: 1.07-7.63, p = 0.042) were the independent and significant predictors of the overall survival. Discussion: Quantification of preoperative NCR and albumin may help surgeons to settle an effective perioperative management, take extra caution, and be aware of post-operative complications of pancreatic cancer patients.
Keywords: Pancreas cancer. Postoperative complication. Neutrophil-to-C-reactive protein ratio.