Jesús S. Sánchez-Díaz, Unidad de Cuidados Intensivos, Hospital de Especialidades Número 14, Instituto Mexicano del Seguro Social (IMSS), Unidad Médica de Alta Especialidad (UMAE), Veracruz, Mexico
Diego Escarraman-Martínez, Departamento de Anestesiología, Centro Médico Nacional “La Raza”, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
Manuel A. Guerrero-Gutiérrez, Unidad de Cuidados Intensivos, Baja Hospital and Medical Center, Baja California; Departamento de Anestesiología Bariátrica, Baja Hospital and Medical Center, Baja California; Mexico
Héctor D. Meza-Comparán, Dirección de Investigación, Instituto Nacional de Geriatría, Mexico City, Mexico
Javier Mancilla-Galindo, División de Posgrado, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
Karla G. Peniche-Moguel, Unidad de Cuidados Intensivos, Hospital de Especialidades Número 14, Instituto Mexicano del Seguro Social (IMSS), Unidad Médica de Alta Especialidad (UMAE), Veracruz, Mexico
Eduardo A. González-Escudero, Unidad de Cuidados Intensivos, Hospital de Especialidades Número 14, Instituto Mexicano del Seguro Social (IMSS), Unidad Médica de Alta Especialidad (UMAE), Veracruz, Mexico
Luis del Carpio-Orantes, Unidad de Cuidados Intensivos, Hospital General de Zona No. 71, IMSS, Veracruz, Mexico
Enrique Monares-Zepeda, Unidad de Cuidados Intensivos, Medical Center ABC, Mexico City, Mexico
Orlando R. Perez-Nieto, Unidad de Cuidados Intensivos, Hospital General San Juan del Rio, Querétaro, Mexico
Eder I. Zamarrón-López, Unidad de Cuidados Intensivos, Hospital General Regional No. 6, IMSS, Ciudad Madero, Tamaulipas, Mexico
Ernesto Deloya-Tomas, Unidad de Cuidados Intensivos, Hospital General San Juan del Rio, Querétaro, Mexico
Verónica Calyeca-Sanchez, Unidad de Cuidados Intensivos, Hospital de Especialidades Número 14, Instituto Mexicano del Seguro Social (IMSS), Unidad Médica de Alta Especialidad (UMAE), Veracruz, Mexico
Ashuin Kammar-García, Dirección de Investigación, Instituto Nacional de Geriatría, Mexico City; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional (IPN), México City. Mexico


Objective: The objective of this study was to assess the association and interaction of laboratory parameters, Simplified Acute Physiology Score II (SAPSII), Modified Shock Index (MSI), and Mannheim Peritonitis Index (MPI) with in-hospital mortality. Material and methods: We conducted a single-center case–control study. Adult patients with abdominal sepsis were included from May 2015 to May 2020. Baseline characteristics, laboratory parameters, SAPSII, MSI, and MPI scores at admission were collected. A principal component (PC) analysis was applied to evaluate variable interactions. In-hospital mortality risk was determined through logistic regression models. Results: One hundred and twenty-seven patients were identified, 60 of which were included for analyses. Non-survivors (48.4%) had a higher frequency of hypertension, lactate and MPI, and lower BE and alactic BE levels. Eight PCs were obtained, PC1 being a linear combination of pH, AG, cAG, alactic BE, bicarbonate, and BE. MPI (OR = 9.87, 95% CI: 3.07-36.61, p = 0.0002), SAPSII (OR = 1.07, 95%CI: 1.01-1.14, p = 0.01), and PC1 (OR = 2.13, 95%CI: 1.12-4.76, p = 0.04) were significantly associated with mortality in univariate analysis, while MPI (OR = 10.1, 95%CI: 3.03-40.06, p = 0.0003) and SAPSII (OR = 1.07, CI95%: 1.01–1.14, p = 0.02) remained significant after adjusting for age and sex. Conclusion: MPI and SAPSII were associated with mortality, although the interaction of laboratory parameters was not.



Keywords: Septic shock. Abdominal sepsis. Mortality.