Veli M. Yazar, Department of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, Turkey
Omer G. Doluoglu, Department of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, Turkey
Berat C. Ozgur, Department of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, Turkey
Muzaffer Çaydere, Department of Pathology. Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, Turkey
Turgay Akgul, Department of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, Turkey
Engin Dogantekin, Department of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, Turkey
Sema Hücümenoglu, Department of Pathology. Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, Turkey
Koray Agras, Department of Urology, Clinic of Ankara Training and Research Hospital, University of Medical Sciences, Ankara, Turkey


Objectives: In the present study, we aimed to investigate the effect of dexpanthenol on wound healing at the histopathological level on cavernous tissue. Materials and methods: Forty-four Wistar albino rats weighing 220-250 g were used. The rats were randomly divided into four groups as Group B, Group S, Group LD, and Group SD. In Group B, the incision was not repaired and left to secondary healing. In Group S, the incision line was repaired with 5/0 polyglactin suture. In Group LD, 0.25 mg/kg dexpanthenol was applied subcutaneously below the repaired wound region once a day during 14 days. In Group SD, 500 mg dexpanthenol was applied intraperitoneally once a day during 14 days. Results: No fibrosis was observed in 8 (80%) rats in group SD. Fibrosis rates were significantly lower in Group SD compared to Group B, Group S, and Group LD (p = 0.013, p = 0.005, and p = 0.003, respectively). Conclusion: Systemic dexpanthenol administration significantly decreased fibrosis in penile fracture model on rats.



Keywords: Dexpanthenol. Fibrosis. Penile fracture. Rat.