Ahmet Bilgi, Department of Gynecology and Obstetrics, Selçuk University Faculty of Medicine, Konya, Turkey
Mustafa C. Terek, Department of Gynecology and Obstetrics, Ege University Faculty of Medicine, Izmir, Turkey
Gürkan Yiğittürk, Department of Histology and Embryology, Mugla Sitki Kocman University Faculty of Medicine, Mugla, Turkey
Dilek Taşkıran, Department of Physiology, Ege University Faculty of Medicine, Izmir, Turkey
Orkun İlgen, Department of Gynecology and Obstetrics, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey
İsmet Hortu, Department of Gynecology and Obstetrics, Ege University Faculty of Medicine, Izmir, Turkey
Bulent Yilmaz, Department of Gynecology and Obstetrics, Recep Tayyip Erdogan University Faculty of Medicine, Rize, Turkey
Cavit Kart, Department of Gynecology and Obstetrics, Karadeniz Technical Unıversity Faculty of Medicine, Trabzon. Turkey
Fazıl Avcı, Department of Gynecology and Obstetrics, Selçuk University Faculty of Medicine, Konya, Turkey
Mehmet Kulhan, Department of Gynecology and Obstetrics, Selçuk University Faculty of Medicine, Konya, Turkey
Objective: Effects of lycopene in prevention of intra-abdominal adhesion formation in a rat model. Methods: Twenty-eight rats were divided into four groups consisting of 7 rats each. Group 1 (only adhesion), Group 2 (adhesion + corn oil), Group 3 (adhesion + 5 mg/kg lycopene), Group 4 (adhesion + 20 mg/kg lycopene). Adhesion score, histopathology, vascular endothelial growth factor (VEGF) H-score, malondialdehyde (MDA), total antioxidant capacity, and VEGF values were measured. Results: There were significantly higher extent, severity, degree, and total adhesion scores in the control and corn-oil group than in the low lycopene and high lycopene group. VEGF H-scores were significantly lower in lycopene-given groups, regardless of dose. When the low lycopene and high lycopene groups were compared in terms of anti-VEGF H-score, no significant difference was observed. Malondialdehyde levels were statistically significantly lower in the control and high lycopene group. Conclusions: Biochemical parameters, histopathological examination, and adhesion scoring revealed that lycopene significantly reduced adhesion formation.
Keywords: Adhesion. Lycopene. Peritoneum. Rat. Vascular endothelial growth factor.