Havva H. Keser-Şahin, Department of Pathology, Hitit University Faculty of Medicine, Çorum, Turkey
Mustafa Şahin, Department of Medical Biochemistry, Hitit University Faculty of Medicine, Çorum, Turkey
Orhan Aslan, Department of General Surgery, Hitit University Faculty of Medicine, Çorum, Turkey
İsmail Sezikli, Department of General Surgery, Hitit University Faculty of Medicine, Çorum, Turkey
Muhammed Kaya, Department of Internal Medicine, Division of Gastroenterology, Hitit University Faculty of Medicine, Çorum, Turkey
Okan Dikker, Department of Medical Biochemistry, University of Health Science Istanbul Prof. Dr. Cemil Taşcıoglu City Hospital, Istanbul, Turkey
Objective: The aim of this study is to investigate the relationship between liver enzymes and lipid profiles in cholecystectomy cases with cholecystitis, cholesterolosis, and cholesterol polyps. Methods: The cholecystectomy cases were divided into 3 groups according to their pathological diagnosis; cholesterolosis and cholelithiasis (Group 1), cholesterolosis (Group 2), and cholesterolosis and cholesterol polyp (Group 3). The groups were subjected to statistical analysis based on age, gender, cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein (HDL), alkaline phosphatase, gamma-glutamyl transferase (GGT), and C-reactive protein values. Results: Of the 227 cases included, 39 (17.2%) were male, and 188 (82.8%) were female. HDL value was significantly lower in men than in women (p = 0.00), while GGT (p = 0.00), aspartate aminotransferase (p = 0.01), and alanine aminotransferase (p = 0.00) values were significantly higher in men. No significant differences were detected in comparisons between pathological diagnostic groups (all p > 0.05). Conclusions: No statistically significant findings were found regarding lipid profile and liver enzyme levels in cases of cholesterolosis, cholelithiasis, and cholesterol polyps. Although it is predicted that the HDL level being significantly lower in men than in women will increase the risk of polyp, no significant difference was detected between the pathological diagnosis groups in terms of gender. Studies containing larger case series are needed to reveal this relationship more clearly.
Keywords: Cholelithiasis. Cholesterolosis. Cholesterol polyp. Lipid profile. Liver enzymes.